World’s First,
Global Pioneer in
Tiger Milk Mushroom Cultivation
From Malaysia’s rainforests, LiGNO Biotech pioneered the world’s first cultivation of the Tiger Milk Mushroom, transforming a centuries-old tradition into a clinically validated wellness solution.






OUR STORY
One Scientist. One Legacy. A Global Scientific Standard.
OUR GENESIS
LiGNO Biotech began not with a corporate business plan, but with a scientific passion and a lifelong mission—to revive, validate, and share one of Malaysia’s most important natural treasures: the Tiger Milk Mushroom (Lignosus rhinocerus).
The tradition
Where Ancestral Wisdom Meets Modern Biotechnology
The journey of LiGNO Biotech begins at a rare convergence: traditional knowledge, scientific curiosity, and Malaysia’s extraordinary biodiversity.
For generations, the Tiger Milk Mushroom existed quietly within the deep tropical rainforests. Its virtues were highly valued and carefully preserved through oral tradition. Yet, because it was exceptionally scarce and entirely untouched by modern research, its true potential remained inaccessible to the wider world.
A national treasure, hidden in plain sight.
That began to change in 2002.
THE TURNING POINT
When National History Met a Personal Calling
At the 2002 International Convention on Biotechnology, Malaysia’s former Prime Minister, Tun Dr. Mahathir Mohamad, addressed the scientific community. In his remarks, he candidly referenced Tiger Milk Mushroom in the context of traditional healing—drawing national attention to a medicinal fungus long overlooked by modern science For many in the audience, it was a compelling reflection.
For Dr. Tan Chon Seng, it was transformative.
The moment resonated deeply. It instantly carried him back to his childhood—to memories of his mother carefully preparing Tiger Milk Mushroom whenever a family member fell ill. An act of pure care rooted in tradition, passed quietly from generation to generation.
Grounded in that memory and trained in the rigors of biotechnology, Dr. Tan recognized his life’s calling: to scientifically validate what generations before him had trusted—through the discipline of modern science.


THE SCIENTIFIC CHALLENGE
Reclaiming a National Treasure from the Wild
The challenge was unprecedented.
At the time, Tiger Milk Mushroom had never been successfully cultivated anywhere in the world. It grew strictly in the wild—rare, unpredictable, and hidden deep underground.
• Without cultivation, there could be no standardization.
• Without standardization, there could be no clinical validation.
• Without science, its immense potential would remain confined to folklore.
Determined to find answers at the source, Dr. Tan and his team ventured deep into the Titiwangsa Range, working closely with the indigenous Orang Asli community of Lata Iskandar, Cameron Highlands.
There, they secured the authentic wild specimen that would lay the foundation for a scientific breakthrough—and a biotechnology revolution.
From Folklore to Hard Science (2002–2008)
What followed was a rigorous, multi-year R&D journey focused on cultivation science, genetics, strain selection, and bioactivity mapping. In 2008, backed by robust data and government support, LiGNO Biotech was formally established.
The breakthroughs achieved by Dr. Tan and his team redefined what was possible for Tiger Milk Mushroom—and established the scientific foundations the global market now relies on:
Patented Cultivation Technology
The world’s first sustainable, and commercially scalable cultivation technology.
The TM02® Gold Standard
A proprietary strain developed for consistent quality and clinically supported respiratory and immune efficacy.
Standardized Dosage Profiles
Defined, measurable parameters ensuring consistent safety, quality, and active bioavailability.
Pioneered Genetic Mapping
The first genetic markers to accurately classify, authenticate, and protect Lignosus rhinocerus.
Expanded Global Taxonomy
The discovery and scientific documentation of two previously unknown Lignosus species.
Nutraceuticals & Supplements
278+
Types of waste we collect
We've got the permits to handle all kinds of waste.
278+
Types of waste we collect

We've got the permits to handle all kinds of waste.
Standardized bioactive for immunity, energy, and wellness.
278+
Types of waste we collect
We've got the permits to handle all kinds of waste.
Key Milestones
2002
- Malaysia’s former Prime Minister Tun Dr. Mahathir Mohamad inspired Dr. Tan Chon Seng to begin research on Tiger Milk Mushroom
2008
- Patented cultivation technology successfully developed
- LiGNO Biotech founded
2009
- Backed by Malaysia’s Ministry of Agriculture for the first cultivation plant
2011
- Tiger Milk Mushroom officially listed as an National Pharmaceutical Regulatory Agency (NPRA) active ingredient in Malaysia
- Launched the first registered Tiger Milk Mushroom product
- Achieved Halal & Organic certifications
- Honored by The Malaysia Book of Records
2012–2019
- Awarded BioNexus status
- Expanded commercialisation of functional mushroom ingredients regionally
- Earned ISO22000, HACCP, GMP certifications
- Multiple innovation and industry awards: HIP5 BioNext, ITEX, MCY 2016 & 2017, Malaysia Health & Wellness Brand
2020 – Present
- Achieved Kosher certification
- Ranked Top 10 SME Corp E50 Award winner
- Accelerated global expansion
2002
- Malaysia’s former Prime Minister Tun Dr. Mahathir Mohamad inspired Dr. Tan Chon Seng to begin research on Tiger Milk Mushroom
2008
- Patented cultivation technology successfully developed
- LiGNO Biotech founded
2009
- Backed by Malaysia’s Ministry of Agriculture for the first cultivation plant
2011
- Tiger Milk Mushroom officially listed as an National Pharmaceutical Regulatory Agency (NPRA) active ingredient in Malaysia
- Launched the first registered Tiger Milk Mushroom product
- Achieved Halal & Organic certifications
- Honored by The Malaysia Book of Records
2012-2019
- Awarded BioNexus status
- Expanded commercialisation of functional mushroom ingredients regionally
- Earned ISO22000, HACCP, GMP certifications
- Multiple innovation and industry awards: HIP5 BioNext, ITEX, MCY 2016 & 2017, Malaysia Health & Wellness Brand
2020-Present
- Achieved Kosher certification
- Ranked Top 10 SME Corp E50 Award winner
- Accelerated global expansion
THE JOURNEY CONTINUES

Dr. Tan’s work established the scientific foundation that made everything that followed possible, from successful cultivation to strain development, and the creation of standardized Tiger Milk Mushroom ingredients.
Today, Tiger Milk Mushroom is no longer confined to traditional knowledge. It is a scientifically developed and globally trusted functional ingredient used in health and wellness applications worldwide.
We have come a long way from Lata Iskandar. But we are not done.
The journey continues. And we invite the world to walk with us.

The impact
The Impact Built for the World
Today, Tiger Milk Mushroom is no longer confined to ancient texts or unpredictable wild harvesting.
Thanks to the scientific bridge Dr. Tan built, it is now a clinically validated, globally trusted functional ingredient—relied upon by leading wellness brands, nutraceutical manufacturers, and healthcare professionals worldwide.
LiGNO Biotech continues to advance functional mushroom science through research, clinical collaboration, and global partnerships.
We have come a long way from the forests of Lata Iskandar. But our pursuit of scientific validation never stops.
“We do not follow trends. We build the scientific foundations that define them.”
Key Milestones
2002
- Malaysia’s former Prime Minister Tun Dr. Mahathir Mohamad inspired Dr. Tan Chon Seng to begin research on Tiger Milk Mushroom
2008
- Patented cultivation technology successfully developed
- LiGNO Biotech founded
2009
- Backed by Malaysia’s Ministry of Agriculture for the first cultivation plant
2011
- Tiger Milk Mushroom officially listed as an National Pharmaceutical Regulatory Agency (NPRA) active ingredient in Malaysia
- Launched the first registered Tiger Milk Mushroom product
- Achieved Halal & Organic certifications
- Honored by The Malaysia Book of Records
2012-2019
- Awarded BioNexus status
- Expanded commercialisation of functional mushroom ingredients regionally
- Earned ISO22000, HACCP, GMP certifications
- Multiple innovation and industry awards: HIP5 BioNext, ITEX, MCY 2016 & 2017, Malaysia Health & Wellness Brand
2020-Present
- Achieved Kosher certification
- Ranked Top 10 SME Corp E50 Award winner
- Accelerated global expansion
Nutraceuticals & Supplements
278+
Types of waste we collect
We've got the permits to handle all kinds of waste.
278+
Types of waste we collect

We've got the permits to handle all kinds of waste.
Standardized bioactive for immunity, energy, and wellness.
278+
Types of waste we collect
We've got the permits to handle all kinds of waste.
Today’s Gold Standard
LiGNO Biotech continues to set the benchmark for functional mushroom ingredients. Through our patented cultivation methods, rigorous quality control, and scientific validation, we deliver consistent, high-efficacy mushrooms trusted by partners around the world.
Key Milestones
2002
- Malaysia’s former Prime Minister Tun Dr. Mahathir Mohamad inspired Dr. Tan Chon Seng to begin research on Tiger Milk Mushroom
2011
- Tiger Milk Mushroom officially listed as an National Pharmaceutical Regulatory Agency (NPRA) active ingredient in Malaysia
- Launched the first registered Tiger Milk Mushroom product
- Achieved Halal & Organic certifications
- Honored by The Malaysia Book of Records
2012–2019
- Awarded BioNexus status
- Expanded commercialisation of functional mushroom ingredients regionally
- Earned ISO22000, HACCP, GMP certifications
- Multiple innovation and industry awards: HIP5 BioNext, ITEX, MCY 2016 & 2017, Malaysia Health & Wellness Brand
Nutraceuticals & Supplements
278+
Types of waste we collect
We've got the permits to handle all kinds of waste.
278+
Types of waste we collect

We've got the permits to handle all kinds of waste.
Standardized bioactive for immunity, energy, and wellness.
278+
Types of waste we collect
We've got the permits to handle all kinds of waste.
Today’s Gold Standard
LiGNO Biotech continues to set the benchmark for functional mushroom ingredients. Through our patented cultivation methods, rigorous quality control, and scientific validation, we deliver consistent, high-efficacy mushrooms trusted by partners around the world.
Key Milestones
2002
- Malaysia’s former Prime Minister Tun Dr. Mahathir Mohamad inspired Dr. Tan Chon Seng to begin research on Tiger Milk Mushroom
2011
- Tiger Milk Mushroom officially listed as an National Pharmaceutical Regulatory Agency (NPRA) active ingredient in Malaysia
- Launched the first registered Tiger Milk Mushroom product
- Achieved Halal & Organic certifications
- Honored by The Malaysia Book of Records
2012–2019
- Awarded BioNexus status
- Expanded commercialisation of functional mushroom ingredients regionally
- Earned ISO22000, HACCP, GMP certifications
- Multiple innovation and industry awards: HIP5 BioNext, ITEX, MCY 2016 & 2017, Malaysia Health & Wellness Brand








