World’s First,
Global Pioneer in
Tiger Milk Mushroom Cultivation
From Malaysia’s rainforests, LiGNO Biotech pioneered the world’s first cultivation of the Tiger Milk Mushroom, transforming a centuries-old tradition into a clinically validated wellness solution.
SCIENTIFIC PUBLICATIONS
Our research is backed by a growing collection of detailed scientific reports that highlight the safety, efficacy, and unique bioactive properties of LiGNO Biotech’s mushroom ingredients. These reports provide in-depth data on cultivation methods, clinical findings, and functional benefits, reinforcing the credibility and evidence-based foundation of our innovations.
| No. | PUBLICATIONS | LINK |
|---|---|---|
| 1 | 十种珍稀食用菌亟待开发（学术期刊）(2003)Dietary Fibers from Mushroom Sclerotia and their Functional Properties (2003) | Read More |
| 2 | Antiproliferative Effects of Sclerotial Polysaccharides from Polyporus. rhinocerus Cooke (Aphyllophoromycetideae) On different Kinds of Leukemic Cells (2008) | Read More |
| 3 | Stimulation of Human Innate Immune Cells by Medicinal Mushroom Sclerotial Polysaccharides (2009) | Read More |
| 4 | Nondigestible Carbohydrates Isolated from Medicinal Mushroom Sclerotia as Novel Prebiotics (2009) | Read More |
| 5 | Immunomodulatory activities of mushroom sclerotial polysaccharides (2011) | Read More |
| 6 | The anti-proliferative activity of sclerotia of Lignosus rhinocerus (2012) | Read More |
| 7 | Nutrient composition, antioxidant properties, and anti-proliferative activity of Lignosus rhinocerus (Cooke) sclerotium (2013) | Read More |
| 8 | Anti-inflammatory effect of the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden, the Tiger Milk mushroom (2014) | Read More |
| 9 | Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells (2015) | Read More |
| 10 | Lion’s Mane, Hericiumerinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study (2015) | Read More |
| 11 | Phytochemical profiles and inhibitory effects of Tiger Milk mushroom (Lignosus rhinocerus) extract on ovalbumin-induced airway inflammation in a rodent model of asthma (2016) | Read More |
| 12 | Fungal Immunomodulatory Protein from Tiger Milk Mushroom, Lignosus rhinocerotis (International Society for Mushroom Science) (2016) | Read More |
| 13 | Characterisation of a New Fungal Immunomodulatory Protein from Tiger Milk mushroom, Lignosus rhinocerotis (2016) | Read More |
| 14 | The Medicinal Properties and Efficacy of Cultivated Tiger Milk Mushroom (Lignosus rhinocerotis TM02®) (International Society for Mushroom Science) (2016) | Read More |
| 15 | Lignosus rhinocerotis on Airway Muscle Relaxation (International Society for Mushroom Science) (2016) | Read More |
| 16 | The Bioactivity of Tiger Milk Mushroom: Malaysia's Prized Medicinal Mushroom (2017) | Read More |
| 17 | Antidiabetic Properties of the Tiger’s Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes), in Streptozotocin-Induced Diabetic Rats (2017) | Read More |
| 18 | Inhibition of Protein Glycation by Tiger Milk Mushroom [Lignosus rhinocerus (Cooke) Ryvarden] and Search for Potential Anti-diabetic Activity-Related Metabolic Pathways by Genomic and Transcriptomic Data Mining | Read More |
| 19 | Bronchodilator effects of Lignosus rhinocerotis extract on rat isolated airways is linked to the blockage of calcium entry (2018) | Read More |
| 20 | A Status Review of the Bioactive Activities of Tiger Milk Mushroom Lignosus rhinocerotis (Cooke) Ryvarden (2018) | Read More |
| 21 | Intranasal administration of Lignosus rhinocerus (Cooke) Ryvarden (Tiger Milk Mushroom) extract attenuates airway inflammation in murine model of allergic asthma (2019) | Read More |
| 22 | Cloning, overexpression, purification and modelling of a lectin (Rhinocelectin) with antiproliferative activity from Tiger Milk Mushroom, Lignosus rhinocerus (2019) | Read More |
| 23 | The Immunomodulating Properties of Tiger Milk Medicinal Mushroom, Lignosus rhinocerus TM02® Cultivar (Agaricomycetes) and Its Associated Carbohydrate Composition (2020) | Read More |
| 24 | Restitution of epithelial cells during intestinal mucosal wound healing (2021) | Read More |
| 25 | Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma (2021) | Read More |
| 26 | Lignosus rhinocerus TM02® sclerotia extract inhibits dengue virus replication and Infection (2021) | Read More |
| 27 | Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus (2021) | Read More |
| 28 | Toxicity Studies of Tiger Milk Mushroom (2010) | Read More |
| 29 | Preclinical Toxicological Evaluations of the Sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk Mushroom (2013) | Read More |
| 30 | Genetic Marker for the Identification of A Malaysian Mushroom, Lignosus rhinocerus (cendawan Susu Rimau) (2010) | Read More |
| 31 | The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties (2014) | Read More |
| 32 | Transcriptome Analysis Revealed Highly Expressed Genes Encoding Secondary Metabolite Pathways and Small Cysteine Rich Proteins in the Sclerotium of Lignosus rhinocerotis (2015) | Read More |
| 33 | Utilisation of Macrofungi Species in Malaysia (2004) | Read More |
| 34 | Utilisation of Fungi by Rural Communities for Food and Medicine in Peninsular Malaysia (2009) | Read More |
| 35 | Breathing New Life to A Malaysia Lost National Treasure – Tiger Milk Mushroom (2012) | Read More |
| 36 | Edible And Medicinal Mushrooms For Sub-Health Intervention And Prevention Of Lifestyle Diseases (2013) | Read More |
| 37 | DNA Bar Code Markers for two new species of Lignosus (Polyporaceae) from Malaysia — L. tigris and L. cameronensis (2014) | Read More |
| 38 | Antiproliferative Activity of Protein Extracts from Lignosus tigris (Chon S. Tan) on MCF7 cell line (International Society for Mushroom Science) (2016) | Read More |
| 39 | Nutritional Evaluation on Lignosus cameronensis C. S. Tan, a medicinal Polyporaceae (2019) | Read More |
| 40 | Peer J tigris HMWP KBH (2020) | Read More |
| No. | PUBLICATIONS | LINK |
|---|---|---|
| 1 | The anti-proliferative activity of sclerotia of Lignosus rhinocerus (2012) | Read More |
| 2 | Nutrient composition, antioxidant properties, and anti-proliferative activity of Lignosus rhinocerus (Cooke) sclerotium (2013) | Read More |
| 3 | Anti-inflammatory effect of the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden, the Tiger Milk mushroom (2014) | Read More |
| 4 | Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells (2015) | Read More |
| 5 | Lion’s Mane, Hericiumerinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study (2015) | Read More |
| 6 | Phytochemical profiles and inhibitory effects of Tiger Milk mushroom (Lignosus rhinocerus) extract on ovalbumin-induced airway inflammation in a rodent model of asthma (2016) | Read More |
| 7 | Fungal Immunomodulatory Protein from Tiger Milk Mushroom, Lignosus rhinocerotis (International Society for Mushroom Science) (2016) | Read More |
| 8 | Characterisation of a New Fungal Immunomodulatory Protein from Tiger Milk mushroom, Lignosus rhinocerotis (2016) | Read More |
| 9 | The Medicinal Properties and Efficacy of Cultivated Tiger Milk Mushroom (Lignosus rhinocerotis TM02®) (International Society for Mushroom Science) (2016) | Read More |
| 10 | Lignosus rhinocerotis on Airway Muscle Relaxation (International Society for Mushroom Science) (2016) | Read More |
| 11 | The Bioactivity of Tiger Milk Mushroom: Malaysia's Prized Medicinal Mushroom (2017) | Read More |
| 12 | Antidiabetic Properties of the Tiger’s Milk Medicinal Mushroom, Lignosus rhinocerotis (Agaricomycetes), in Streptozotocin-Induced Diabetic Rats (2017) | Read More |
| 13 | Inhibition of Protein Glycation by Tiger Milk Mushroom [Lignosus rhinocerus (Cooke) Ryvarden] and Search for Potential Anti-diabetic Activity-Related Metabolic Pathways by Genomic and Transcriptomic Data Mining | Read More |
| 14 | Bronchodilator effects of Lignosus rhinocerotis extract on rat isolated airways is linked to the blockage of calcium entry (2018) | Read More |
| 15 | A Status Review of the Bioactive Activities of Tiger Milk Mushroom Lignosus rhinocerotis (Cooke) Ryvarden (2018) | Read More |
| 16 | Intranasal administration of Lignosus rhinocerus (Cooke) Ryvarden (Tiger Milk Mushroom) extract attenuates airway inflammation in murine model of allergic asthma (2019) | Read More |
| 17 | Cloning, overexpression, purification and modelling of a lectin (Rhinocelectin) with antiproliferative activity from Tiger Milk Mushroom, Lignosus rhinocerus (2019) | Read More |
| 18 | The Immunomodulating Properties of Tiger Milk Medicinal Mushroom, Lignosus rhinocerus TM02® Cultivar (Agaricomycetes) and Its Associated Carbohydrate Composition (2020) | Read More |
| 19 | Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma (2021) | Read More |
| 20 | Lignosus rhinocerus TM02® sclerotia extract inhibits dengue virus replication and Infection (2021) | Read More |
| 21 | Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus (2021) | Read More |
| 22 | Toxicity Studies of Tiger Milk Mushroom (2010) | Read More |
| 23 | Preclinical Toxicological Evaluations of the Sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk Mushroom (2013) | Read More |
| 24 | Genetic Marker for the Identification of A Malaysian Mushroom, Lignosus rhinocerus (cendawan Susu Rimau) (2010) | Read More |
| 25 | The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties (2014) | Read More |
| 26 | Transcriptome Analysis Revealed Highly Expressed Genes Encoding Secondary Metabolite Pathways and Small Cysteine Rich Proteins in the Sclerotium of Lignosus rhinocerotis (2015) | Read More |
| 27 | Breathing New Life to A Malaysia Lost National Treasure – Tiger Milk Mushroom (2012) | Read More |
| 28 | DNA Bar Code Markers for two new species of Lignosus (Polyporaceae) from Malaysia — L. tigris and L. cameronensis (2014) | Read More |
| 29 | Antiproliferative Activity of Protein Extracts from Lignosus tigris (Chon S. Tan) on MCF7 cell line (International Society for Mushroom Science) (2016) | Read More |
| 30 | Nutritional Evaluation on Lignosus cameronensis C. S. Tan, a medicinal Polyporaceae (2019) | Read More |
| 31 | Peer J tigris HMWP KBH (2020) | Read More |
| 32 | 十种珍稀食用菌亟待开发（学术期刊）(2003)Dietary Fibers from Mushroom Sclerotia and their Functional Properties (2003) | Read More |
| 33 | Antiproliferative Effects of Sclerotial Polysaccharides from Polyporus. rhinocerus Cooke (Aphyllophoromycetideae) On different Kinds of Leukemic Cells (2008) | Read More |
| 34 | Stimulation of Human Innate Immune Cells by Medicinal Mushroom Sclerotial Polysaccharides (2009) | Read More |
| 35 | Nondigestible Carbohydrates Isolated from Medicinal Mushroom Sclerotia as Novel Prebiotics (2009) | Read More |
| 36 | Immunomodulatory activities of mushroom sclerotial polysaccharides (2011) | Read More |
| 37 | Restitution of epithelial cells during intestinal mucosal wound healing (2021) | Read More |
| 38 | Utilisation of Macrofungi Species in Malaysia (2004) | Read More |
| 39 | Utilisation of Fungi by Rural Communities for Food and Medicine in Peninsular Malaysia (2009) | Read More |
| 40 | Edible And Medicinal Mushrooms For Sub-Health Intervention And Prevention Of Lifestyle Diseases (2013) | Read More |
| PUBLICATIONS | LINK | |
|---|---|---|
| 1 | Genetic Marker for the Identification of A Malaysian Mushroom, Lignosus rhinocerus (cendawan Susu Rimau) (2010) | Read More |
| 2 | The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties (2014) | Read More |
| 3 | Transcriptome Analysis Revealed Highly Expressed Genes Encoding Secondary Metabolite Pathways and Small Cysteine Rich Proteins in the Sclerotium of Lignosus rhinocerotis (2015) | Read More |
| PUBLICATIONS | LINK | |
|---|---|---|
| 1 | Utilisation of Macrofungi Species in Malaysia (2004) | Read More |
| 2 | Utilisation of Fungi by Rural Communities for Food and Medicine in Peninsular Malaysia (2009) | Read More |
| 3 | Breathing New Life to A Malaysia Lost National Treasure – Tiger Milk Mushroom (2012) | Read More |
| 4 | Edible And Medicinal Mushrooms For Sub-Health Intervention And Prevention Of Lifestyle Diseases (2013) | Read More |
| 5 | DNA Bar Code Markers for two new species of Lignosus (Polyporaceae) from Malaysia — L. tigris and L. cameronensis (2014) | Read More |
| 6 | Antiproliferative Activity of Protein Extracts from Lignosus tigris (Chon S. Tan) on MCF7 cell line (International Society for Mushroom Science) (2016) | Read More |
| 7 | Nutritional Evaluation on Lignosus cameronensis C. S. Tan, a medicinal Polyporaceae (2019) | Read More |
| 8 | Peer J tigris HMWP KBH (2020) | Read More |
